In a far distant future, a psionic hormone was discovered in the human brain, granting people extra-sensory powers and changing the world as we know it. Just as humanity was entering this new era, deranged mutants known as Others began to descend from the sky with a thirst for human brains. Highly resistant to conventional attack methods, extreme measures needed to be taken to battle the overwhelming threat and preserve humanity. Those with acute extra-sensory abilities, known as psionics, were our chance to fight the onslaught from above. To this day, psionics have been scouted for their talents and recruited to the Other Suppression Force (OSF), humanity's last line of defense.

Take on the role of Yuito Sumeragi, a new recruit to the OSF aiming to become an elite psionic like the one who saved him as a child. Armed with a talent in psycho-kinesis, explore the futuristic city of New Himuka and uncover the mysteries of a Brain Punk future caught between technology and psychic abilities in SCARLET NEXUS.